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KMID : 0374920180390010023
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Inje Medical Journal
2018 Volume.39 No. 1 p.23 ~ p.31
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Effects of Sugar Control on Motor Manifestations in Parkinson's Disease with Diabetes Mellitus
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Lee Jae-Jung
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Abstract
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Background and purpose: Converging evidences indicated close relationships between Parkinson's disease (PD) and diabetes mellitus (DM). The prevalence of PD is relatively high in patients with DM, and PD patients have higher risk of altered glucose metabolism or increased insulin resistance. The present study investigated the effects of sugar control in motor manifestations of de novo PD patients.
Methods: Consecutively recruited 25 de novo PD patients who were also diagnosed with DM were subdivided into either group of well-controlled (n = 13) or poorly controlled DM (n = 12) by cut-off value of 7.0 of HbA1c. Age and Unified Parkinson's Disease Rating Scale (UPDRS) III scores were matched between two groups, and alterations of UPDRS III scores were compared over 1 year of follow up.
Results: The well-controlled DM group showed significantly better improvement of UPDRS III scores (baseline to 1 year after, 37.4 ± 9.2 to 24.3 ± 6.5) compared to poorly controlled group (37.8 ± 10.6 to 30.2 ± 7.2) over 1 year of follow up (gap of UPDRS III score, - 13.2 ± 9.2 vs 7.2 ± 6.9; p, 0.013). Higher HbA1c were highly associated with lesser improvement of UPDRS III scores (r, 0.563; 95 % CI, 0.216 ? 0.784; p, 0.003).
Conclusions: Our data demonstrated that poorly controlled DM might have detrimental effect on motor improvements in patients with PD. Strict sugar control could be a promising strategy to improve motor manifestation in PD.
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KEYWORD
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Parkinson's disease, Diabetes mellitus, motor progression
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